Introduction to plant and process safety; Principles and methods of labor safety and health protection, Determination, and evaluation of hazardous properties of substances, Materials handling fire control, Loss prevention working with machinery and apparatus, Accidents and loss statistics, and nature of the accident/hazardous processes; Toxicology: toxic materials and biological response, dose-response relationships and models;  Threshold does and its definition; Material safety data sheets and industrial hygiene evaluation; Safety devices: personal safety devices and general hygiene management – ventilations; Fire and Explosions: definition, flammability characteristics and explosion, design to prevent fires and explosions by inverting, purging, ventilation, sprinkler system, static electricity control; Relief and relief sizing in vapor/gas, liquid and run-away reaction services, Electrical safety, Electrical hazards and protection majors, safety in lifting and handling of materials.